NASA hopes to have humans landing on the Moon by 2020 and occupying the surface by 2024, at least for a week at a time. The base would be located on one of the lunar poles to allow for almost continuous solar energy (and access to the limited water below the surface). And we would allow other nations to visit and/or participate in the project.
Of course, the Moon would also operate as a staging ground for a trip to Mars, the strongest argument for setting up there in the first place.
"Using the space station and building an outpost on the moon to prepare for the trip to Mars are critical milestones in America's quest to become a truly spacefaring nation," Griffin writes. "I think that we should want that. I want that. I want it for the American people, for my grandchildren, for my great-grandchildren."
I still say we should have a new race to the moon, but this time by commercial companies. This does not mean a new homesteading program, but NASA could be a partner in some innovative projects. The Moon project will take considerable funding, so all options should be explored.
Besides, the International Space Station is not exactly the most successfully model. It seems to represent PR for space more than real science. Of course, the ISS could prove useful in that the space station modules might be reconfigured for placement on the Moon. Yes, NASA is creating a trailor park on the Moon's surface. But its a start. Did you expect the Jetsons?
For more, visit NASA's Moon site.
Also, take a look at the Space Foundation's publication "The Case for Space." This document offers some good support for the Moon and Mars missions.