Presuming galactic occupation seems like a tall order, yet a March 2013 paper by the Future of Humanity Institute in the UK discussed how our own civilization could expand into the Milky Way and other galaxies. Here is the abstract in the paper titled "Eternity in Six Hours: Intergalactic Spreading of Intelligent Life and Sharpening the Fermi Paradox":
The Fermi paradox is the discrepancy between the strong likelihood of alien intelligent life emerging (under a wide variety of assumptions) and the absence of any visible evidence for such emergence. In this paper, we extend the Fermi paradox to not only life in this galaxy, but to other galaxies as well. We do this by demonstrating that travelling between galaxies – indeed even launching a colonisation project for the entire reachable universe – is a relatively simple task for a star-spanning civilisation, requiring modest amounts of energy and resources. We start by demonstrating that humanity itself could likely accomplish such a colonisation project in the foreseeable future, should we want to. Given certain technological assumptions, such as improved automation, the task of constructing Dyson spheres, designing replicating probes, and launching them at distant galaxies, become quite feasible. We extensively analyse the dynamics of such a project, including issues of deceleration and collision with particles in space. Using similar methods, there are millions of galaxies that could have reached us by now. This results in a considerable sharpening of the Fermi paradox.This is amazing conjecture, and it is the last part that stumped the Penn State University researchers; if we can envision such a future for ourselves, where are such civilizations from other parts of the universe or even within our own galaxy? Plenty to ponder.