First, a Russian Soyuz spacecraft delivered three new crew members to the station - US astronaut Robert Shane and Russian cosmonauts Sergei Ryzhikov and Andrei Borisenko. One could even argue a fourth crew member accompanied them - the relics of Saint Seraphim of Sarov.
Second, Orbital ATK's Cygnus cargo ship also arrived at the ISS. Orbital ATK knows these missions are not mundane having lost a rocket and Cygnus cargo ship two years ago.
Someday we may see such traffic heading to the Moon and Mars as well. However, the Orbital ATK mishap, SpaceX rocket explosions, and recent ExoMars lander failure shows that the space industry is still facing enormous risks. Fortunately, all of the missions just named did not involve human passengers. That adds a whole new level of risk and related risk management.
Image Credit: The photo at the top from NASA shows the new six-member Expedition 49 crew gathers in the Zvezda service module. The three newest arrivals (front row from left) Andrey Borisenko, Sergey Ryzhikov and Shane Kimbrough talk to family members and mission officials back on Earth. In the back row from left are, Kate Rubins, Anatoly Ivanishin and Takuya Onishi. The bottom photo shows the Orbital ATK Cygnus cargo ship arriving at the ISS and is also from NASA.